Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens μ-opiate-mediated feeding behavior
ML Perry, BA Baldo, ME Andrzejewski… - Behavioural brain …, 2009 - Elsevier
Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine
(10μg/0.5 μl), markedly reduced fat intake elicited by intra-Acb treatment of the μ-opioid
receptor agonist, DAMGO, with 30min and 4h pretreatment intervals. Intra-Acb scopolamine
infusions also reduced food intake in food-deprived rats, but not water intake in water-
deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding,
perhaps via interactions with the striatal opioid system.
(10μg/0.5 μl), markedly reduced fat intake elicited by intra-Acb treatment of the μ-opioid
receptor agonist, DAMGO, with 30min and 4h pretreatment intervals. Intra-Acb scopolamine
infusions also reduced food intake in food-deprived rats, but not water intake in water-
deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding,
perhaps via interactions with the striatal opioid system.
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